Anthracyclines: is more, better and/or more dangerous?

Sometimes, more is better.

(See the article by El Sahly et al, on pages 703–12.) Influenza causes significant morbidity and mortality with an estimated 36 000 attributable deaths in the United States annually [1]. Human immunodefi-ciency virus (HIV) infection, specifically , advanced disease (CD4 count ,200 cells/lL), has been associated with excess morbidity and mortality [2]. With the use of combination antiretroviral ...

Is More Entrepreneurship better?

We develop a new perspective on the boundary of the firm that is consistent with the empirical observation that the share of entrepreneurs first decreases and then increases in the course of economic development. Existing theory based on transaction costs (Coase, 1937, and subsequent literature) is difficult to relate to these well-established dynamics. Our approach focuses on changing incentiv...

Is more always better

Is more always better? We address this question in the context of bibliometric indices that aim to assess the scientific impact of individual researchers by counting their number of highly cited publications. We propose a simple model in which the number of citations of a publication depends not only on the scientific impact of the publication but also on other ‘random’ factors. Our model indic...

Is more better?

When more is better

Nutrition support of critically ill patients with sepsis is one of the most debated issues among intensivists. The latest international sepsis guidelines recommend the prescription of a low volume of feeds through gastric or intestinal enteral nutrition (EN) for 7 days after admission to the ICU. The data to support such recommendations are scarce, and large trials are needed to clarify this is...